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Biophysical Fitness Landscapes for Transcription Factor Binding Sites

Phenotypic states and evolutionary trajectories available to cell populations are ultimately dictated by complex interactions among DNA, RNA, proteins, and other molecular species. Here we study how evolution of gene regulation in a single-cell eukaryote S. cerevisiae is affected by interactions bet...

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Autores principales: Haldane, Allan, Manhart, Michael, Morozov, Alexandre V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091707/
https://ncbi.nlm.nih.gov/pubmed/25010228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003683
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