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The Fitness Landscapes of cis-Acting Binding Sites in Different Promoter and Environmental Contexts
The biophysical nature of the interaction between a transcription factor and its target sequences in vitro is sufficiently well understood to allow for the effects of DNA sequence alterations on affinity to be predicted. But even in relatively simple in vivo systems, the complexities of promoter org...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2912393/ https://ncbi.nlm.nih.gov/pubmed/20686658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001042 |
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