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Probing the Informational and Regulatory Plasticity of a Transcription Factor DNA–Binding Domain

Transcription factors have two functional constraints on their evolution: (1) their binding sites must have enough information to be distinguishable from all other sequences in the genome, and (2) they must bind these sites with an affinity that appropriately modulates the rate of transcription. Sin...

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Main Authors: Shultzaberger, Ryan K., Maerkl, Sebastian J., Kirsch, Jack F., Eisen, Michael B.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315485/
https://ncbi.nlm.nih.gov/pubmed/22496663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002614
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