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Evolution of new regulatory functions on biophysically realistic fitness landscapes

Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isola...

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Vydáno v:Nat Commun
Hlavní autoři: Friedlander, Tamar, Prizak, Roshan, Barton, Nicholas H., Tkačik, Gašper
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548793/
https://ncbi.nlm.nih.gov/pubmed/28790313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00238-8
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