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Evolution of new regulatory functions on biophysically realistic fitness landscapes

Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isola...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Friedlander, Tamar, Prizak, Roshan, Barton, Nicholas H., Tkačik, Gašper
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548793/
https://ncbi.nlm.nih.gov/pubmed/28790313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00238-8
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