Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme

Thioredoxin reductases (TrxRs) from mammalian cells contain an essential selenocysteine residue in the conserved C-terminal sequence Gly-Cys-SeCys-Gly forming a selenenylsulfide in the oxidized enzyme. Reduction by NADPH generates a selenolthiol, which is the active site in reduction of Trx. The thr...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Sandalova, Tatyana, Zhong, Liangwei, Lindqvist, Ylva, Holmgren, Arne, Schneider, Gunter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2001
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC55487/
https://ncbi.nlm.nih.gov/pubmed/11481439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171178698
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia