Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme

Thioredoxin reductases (TrxRs) from mammalian cells contain an essential selenocysteine residue in the conserved C-terminal sequence Gly-Cys-SeCys-Gly forming a selenenylsulfide in the oxidized enzyme. Reduction by NADPH generates a selenolthiol, which is the active site in reduction of Trx. The thr...

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Hlavní autoři: Sandalova, Tatyana, Zhong, Liangwei, Lindqvist, Ylva, Holmgren, Arne, Schneider, Gunter
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2001
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC55487/
https://ncbi.nlm.nih.gov/pubmed/11481439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171178698
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