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RasGRP1 Is an Essential Signaling Molecule For Development of B1a Cells With Autoantigen Receptors()

B1a cells, particularly the PD-L2(+) B1a cell subset, are enriched with autoantigen-specific receptors. However, the underlying molecular mechanism responsible for the skewed selection of autoreactive B1a cells remains unclear. Here we find that B1 cells express only RasGRP1, whereas B2 cells expres...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Guo, Benchang, Rothstein, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548536/
https://ncbi.nlm.nih.gov/pubmed/26851222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502132
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