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Beyond transcription factors: how oncogenic signaling reshapes the epigenetic landscape
Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise due to mu...
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| Publicado en: | Nat Rev Cancer |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5548460/ https://ncbi.nlm.nih.gov/pubmed/27220480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc.2016.41 |
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