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Beyond transcription factors: how oncogenic signaling reshapes the epigenetic landscape

Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise due to mu...

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Detalhes bibliográficos
Publicado no:Nat Rev Cancer
Main Authors: Liu, Fan, Wang, Lan, Perna, Fabiana, Nimer, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548460/
https://ncbi.nlm.nih.gov/pubmed/27220480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc.2016.41
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