Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation–inactivation cycle

IFN-γ treatment of cells leads to tyrosine phosphorylation of signal transducer and activator of transcription (STAT) 1 followed by dimerization through a reciprocal Src homology 2–phosphotyrosine interaction near the –COOH end of each monomer, forming a parallel structure that accumulates in the nu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhong, Minghao, Henriksen, Melissa A., Takeuchi, Kenji, Schaefer, Olaf, Liu, Bin, Hoeve, Johanna ten, Ren, Zhiyong, Mao, Xiang, Chen, Xiaomin, Shuai, Ke, Darnell, James E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC554839/
https://ncbi.nlm.nih.gov/pubmed/15753310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501063102
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