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Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model()

Liver fibrosis and cirrhosis result from uncontrolled secretion and accumulation of extracellular matrix (ECM) proteins by hepatic stellate cells (HSCs) that are activated by liver injury and inflammation. Despite the progress in understanding the biology liver fibrogenesis and the identification of...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Karthikeyan, Swathi, Potter, James J., Geschwind, Jean-Francois, Sur, Surojit, Hamilton, James P., Vogelstein, Bert, Kinzler, Kenneth W., Mezey, Esteban, Ganapathy-Kanniappan, Shanmugasundaram
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548097/
https://ncbi.nlm.nih.gov/pubmed/26525850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.10.101
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