Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin

Activation of hepatic stellate cells (HSCs) is an integral component of the wound‐healing process in liver injury/inflammation. However, uncontrolled activation of HSCs leads to constant secretion of collagen‐rich extracellular matrix (ECM) proteins, resulting in liver fibrosis. The enhanced ECM syn...

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Dades bibliogràfiques
Publicat a:J Cell Mol Med
Autors principals: Gajendiran, Priya, Vega, Leonel Iglesias, Itoh, Kie, Sesaki, Hiromi, Vakili, Mohammad Reza, Lavasanifar, Afsaneh, Hong, Kelvin, Mezey, Esteban, Ganapathy‐Kanniappan, Shanmugasundaram
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867155/
https://ncbi.nlm.nih.gov/pubmed/29397578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13501
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