Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin

Activation of hepatic stellate cells (HSCs) is an integral component of the wound‐healing process in liver injury/inflammation. However, uncontrolled activation of HSCs leads to constant secretion of collagen‐rich extracellular matrix (ECM) proteins, resulting in liver fibrosis. The enhanced ECM syn...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Gajendiran, Priya, Vega, Leonel Iglesias, Itoh, Kie, Sesaki, Hiromi, Vakili, Mohammad Reza, Lavasanifar, Afsaneh, Hong, Kelvin, Mezey, Esteban, Ganapathy‐Kanniappan, Shanmugasundaram
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867155/
https://ncbi.nlm.nih.gov/pubmed/29397578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13501
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