AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34(+) cells, allowing nerve growth factor-induced expansion

The AML1-ETO fusion protein, generated by the t(8;21) in acute myeloid leukemia (AML), exerts dominant-negative functions and a variety of gains of function, including a positive effect on the growth of primary human CD34(+) hematopoietic stem/progenitor cells. We now show that AML1-ETO expression u...

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Main Authors: Mulloy, James C., Jankovic, Vladimir, Wunderlich, Mark, Delwel, Ruud, Cammenga, Jorg, Krejci, Ondrej, Zhao, Hui, Valk, Peter J. M., Lowenberg, Bob, Nimer, Stephen D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC554792/
https://ncbi.nlm.nih.gov/pubmed/15731354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404701102
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