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p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death
Chromosomal translocation (8;21) is present in 10% to 15% of patients with acute myeloid leukemia. Expression of the AML1-ETO (AE) fusion protein alone is not sufficient to induce leukemia, but the nature of the additional genetic alterations is unknown. It is unclear whether AE facilitates acquisit...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234055/ https://ncbi.nlm.nih.gov/pubmed/17975013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-093682 |
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