p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death

Chromosomal translocation (8;21) is present in 10% to 15% of patients with acute myeloid leukemia. Expression of the AML1-ETO (AE) fusion protein alone is not sufficient to induce leukemia, but the nature of the additional genetic alterations is unknown. It is unclear whether AE facilitates acquisit...

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Hlavní autoři: Krejci, Ondrej, Wunderlich, Mark, Geiger, Hartmut, Chou, Fu-Sheng, Schleimer, David, Jansen, Michael, Andreassen, Paul R., Mulloy, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234055/
https://ncbi.nlm.nih.gov/pubmed/17975013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-093682
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