p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death

Chromosomal translocation (8;21) is present in 10% to 15% of patients with acute myeloid leukemia. Expression of the AML1-ETO (AE) fusion protein alone is not sufficient to induce leukemia, but the nature of the additional genetic alterations is unknown. It is unclear whether AE facilitates acquisit...

Full description

Saved in:
Bibliographic Details
Main Authors: Krejci, Ondrej, Wunderlich, Mark, Geiger, Hartmut, Chou, Fu-Sheng, Schleimer, David, Jansen, Michael, Andreassen, Paul R., Mulloy, James C.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234055/
https://ncbi.nlm.nih.gov/pubmed/17975013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-093682
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items