The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO

AML1-ETO (AE) is a fusion product of translocation (8;21) that accounts for 40% of M2 type acute myeloid leukemia (AML). In addition to its role in promoting preleukemic hematopoietic cell self-renewal, AE represses DNA repair genes, which leads to DNA damage and increased mutation frequency. Althou...

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Autori principali: Chou, Fu-Sheng, Griesinger, Andrea, Wunderlich, Mark, Lin, Shan, Link, Kevin A., Shrestha, Mahesh, Goyama, Susumu, Mizukawa, Benjamin, Shen, Shuhong, Marcucci, Guido, Mulloy, James C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
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Plenary Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412344/
https://ncbi.nlm.nih.gov/pubmed/22337712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-403212
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