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Intratumoral STING activation with T-cell checkpoint modulation generates systemic antitumor immunity

Coordinated manipulation of independent immune regulatory pathways in the tumor microenvironment – including blockade of T-cell checkpoint receptors and reversal of suppressive myeloid programs – can render aggressive cancers susceptible to immune rejection. Elevated toxicity associated with combina...

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Bibliographic Details
Published in:Cancer Immunol Res
Main Authors: Ager, Casey R., Reilley, Matthew J., Nicholas, Courtney, Bartkowiak, Todd, Jaiswal, Ashvin R., Curran, Michael A.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547907/
https://ncbi.nlm.nih.gov/pubmed/28674082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0049
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