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Site-directed spin labeling reveals a conformational switch in the phosphorylation domain of smooth muscle myosin
We have used site-directed spin labeling and EPR spectroscopy to detect structural changes within the regulatory light chain (RLC) of smooth muscle myosin upon phosphorylation. Smooth muscle contraction is activated by phosphorylation of S19 on RLC, but the structural basis of this process is unknow...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC554790/ https://ncbi.nlm.nih.gov/pubmed/15753305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401664102 |
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