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Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3
IFN regulatory factor 3 (IRF3), a constitutively expressed protein localizing largely to the cytoplasm, is a primary effector of the innate immune response. Infection can trigger the phosphorylation, dimerization, and nuclear translocation of IRF3, where the factor stimulates the expression and rele...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC554789/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15741273/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408376102 |
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