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Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3

IFN regulatory factor 3 (IRF3), a constitutively expressed protein localizing largely to the cytoplasm, is a primary effector of the innate immune response. Infection can trigger the phosphorylation, dimerization, and nuclear translocation of IRF3, where the factor stimulates the expression and rele...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Barro, Mario, Patton, John T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2005
Aiheet:
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC554789/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15741273/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408376102
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