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Rotavirus NSP1 Mediates Degradation of Interferon Regulatory Factors through Targeting of the Dimerization Domain

Rotavirus nonstructural protein NSP1 can inhibit expression of interferon (IFN) and IFN-stimulated gene products by inducing proteasome-mediated degradation of IFN-regulatory factors (IRFs), including IRF3, IRF5, and IRF7. All IRF proteins share an N-terminal DNA-binding domain (DBD), and IRF3, IRF5...

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Библиографические подробности
Главные авторы: Arnold, Michelle M., Barro, Mario, Patton, John T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754143/
https://ncbi.nlm.nih.gov/pubmed/23824805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01146-13
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