Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A

CD44 has been postulated as a cell surface coreceptor for augmenting receptor tyrosine kinase (RTK) signaling. However, how exactly CD44 triggers RTK-dependent signaling remained largely unclear. Here we report an unexpected mechanism by which the CD44s splice isoform is internalized into endosomes...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Wei, Zhang, Honghong, Liu, Sali, Kim, Chung Kwon, Xu, Yilin, Hurley, Lisa A., Nishikawa, Ryo, Nagane, Motoo, Hu, Bo, Stegh, Alexander H., Cheng, Shi-Yuan, Cheng, Chonghui
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547599/
https://ncbi.nlm.nih.gov/pubmed/28716909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701289114
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