CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

Epithelial-mesenchymal transition (EMT) is a tightly regulated process that is critical for embryogenesis but is abnormally activated during cancer metastasis and recurrence. Here we show that a switch in CD44 alternative splicing is required for EMT. Using both in vitro and in vivo systems, we have...

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Detalhes bibliográficos
Main Authors: Brown, Rhonda L., Reinke, Lauren M., Damerow, Marin S., Perez, Denise, Chodosh, Lewis A., Yang, Jing, Cheng, Chonghui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049398/
https://ncbi.nlm.nih.gov/pubmed/21393860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44540
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