CD44 splice isoform switching determines breast cancer stem cell state

Although changes in alternative splicing have been observed in cancer, their functional contributions still remain largely unclear. Here we report that splice isoforms of the cancer stem cell (CSC) marker CD44 exhibit strikingly opposite functions in breast cancer. Bioinformatic annotation in patien...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Zhang, Honghong, Brown, Rhonda L., Wei, Yong, Zhao, Pu, Liu, Sali, Liu, Xuan, Deng, Yu, Hu, Xiaohui, Zhang, Jing, Gao, Xin D., Kang, Yibin, Mercurio, Arthur M., Goel, Hira Lal, Cheng, Chonghui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362815/
https://ncbi.nlm.nih.gov/pubmed/30692202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.319889.118
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