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Arc mRNA Docks Precisely at the Base of Individual Dendritic Spines Indicating the Existence of a Specialized Microdomain for Synapse-Specific mRNA Translation

Arc (aka Arg 3.1) is induced by neural activity and learning experience. Arc mRNA is rapidly exported into dendrites where it localizes near activated synapses. By imaging green fluorescent protein (GFP)-tagged mRNA in living neurons in culture, we show that fusion transcripts containing the Arc 3′U...

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Publié dans:J Comp Neurol
Auteurs principaux: Dynes, Joseph L., Steward, Oswald
Format: Artigo
Langue:Inglês
Publié: 2012
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546873/
https://ncbi.nlm.nih.gov/pubmed/22350812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.23073
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