Histone Deacetylase Inhibitor SAHA Is a Promising Treatment of Cushing Disease

CONTEXT: Remission failure following transsphenoidal surgery in Cushing disease (CD) from pituitary corticotroph tumors (CtTs) remains clinically challenging. Histone deacetylase inhibitors (HDACis) are antitumor drugs approved for clinical use, with the potential to affect adrenocorticotropin hormo...

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Bibliographic Details
Published in:J Clin Endocrinol Metab
Main Authors: Lu, Jie, Chatain, Grégoire P., Bugarini, Alejandro, Wang, Xiang, Maric, Dragan, Walbridge, Stuart, Zhuang, Zhengping, Chittiboina, Prashant
Format: Artigo
Language:Inglês
Published: Endocrine Society 2017
Subjects:
Clinical Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546859/
https://ncbi.nlm.nih.gov/pubmed/28505327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-00464
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