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Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid

Histone deacetylase (HDAC) proteins have emerged as targets for anti-cancer therapeutics, with several inhibitors used in the clinic, including suberoylanilide hydroxamic acid (SAHA, vorinostat). Because SAHA and many other inhibitors target all or most of the 11 human HDAC proteins, the creation of...

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Détails bibliographiques
Publié dans:Arch Pharm (Weinheim)
Auteurs principaux: Bieliauskas, Anton V., Weerasinghe, Sujith V. W., Negmeldin, Ahmed T., Pflum, Mary Kay H.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927578/
https://ncbi.nlm.nih.gov/pubmed/27062198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ardp.201500472
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