An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein

Prion diseases are neurodegenerative conditions characterized by the conformational conversion of the cellular prion protein (PrP(C)), an endogenous membrane glycoprotein of uncertain function, into PrP(Sc), a pathological isoform that replicates by imposing its abnormal folding onto PrP(C) molecule...

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Publicat a:PLoS One
Autors principals: Stincardini, Claudia, Massignan, Tania, Biggi, Silvia, Elezgarai, Saioa R., Sangiovanni, Valeria, Vanni, Ilaria, Pancher, Michael, Adami, Valentina, Moreno, Jorge, Stravalaci, Matteo, Maietta, Giulia, Gobbi, Marco, Negro, Alessandro, Requena, Jesús R., Castilla, Joaquín, Nonno, Romolo, Biasini, Emiliano
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546605/
https://ncbi.nlm.nih.gov/pubmed/28787011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182589
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