A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein

Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrP(C)) into PrP(Sc), a self-replicating isoform (prion) that accumulates in the central nervous system of affected individuals. The structure of PrP(Sc) is poorly define...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Massignan, Tania, Cimini, Sara, Stincardini, Claudia, Cerovic, Milica, Vanni, Ilaria, Elezgarai, Saioa R., Moreno, Jorge, Stravalaci, Matteo, Negro, Alessandro, Sangiovanni, Valeria, Restelli, Elena, Riccardi, Geraldina, Gobbi, Marco, Castilla, Joaquín, Borsello, Tiziana, Nonno, Romolo, Biasini, Emiliano
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791597/
https://ncbi.nlm.nih.gov/pubmed/26976106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23180
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