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Bortezomib Induces Neuropathic Pain through Protein Kinase C-Mediated Activation of Presynaptic NMDA Receptors in the Spinal Cord

Chemotherapeutic drugs, including bortezomib, often cause painful peripheral neuropathy, which is a severe dose-limiting adverse effect experienced by many cancer patients. The glutamate N-methyl-D-aspartate receptors (NMDARs) at the spinal cord level are critically involved in the synaptic plastici...

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Опубликовано в: :Neuropharmacology
Главные авторы: Xie, Jing-Dun, Chen, Shao-Rui, Chen, Hong, Pan, Hui-Lin
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546238/
https://ncbi.nlm.nih.gov/pubmed/28663117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.06.027
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