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Bortezomib Induces Neuropathic Pain through Protein Kinase C-Mediated Activation of Presynaptic NMDA Receptors in the Spinal Cord
Chemotherapeutic drugs, including bortezomib, often cause painful peripheral neuropathy, which is a severe dose-limiting adverse effect experienced by many cancer patients. The glutamate N-methyl-D-aspartate receptors (NMDARs) at the spinal cord level are critically involved in the synaptic plastici...
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| Publicado en: | Neuropharmacology |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5546238/ https://ncbi.nlm.nih.gov/pubmed/28663117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.06.027 |
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