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Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords

Abstract Calcineurin inhibitors, such as cyclosporin A and tacrolimus (FK506), have played a pivotal role in the preservation of allograft function. However, these drugs can cause unexplained severe pain in patients, often referred to as calcineurin inhibitor-induced pain syndrome (CIPS). Although c...

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Autores principales: Chen, Shao-Rui, Hu, Yi-Min, Chen, Hong, Pan, Hui-Lin
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903361/
https://ncbi.nlm.nih.gov/pubmed/24081160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.263814
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