Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice

Virus-related type 2 diabetes is commonly observed in individuals infected with the hepatitis C virus (HCV); however, the underlying molecular mechanisms remain unknown. Our aim was to unravel these mechanisms using FL-N/35 transgenic mice expressing the full HCV ORF. We observed that these mice dis...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Lerat, Hervé, Imache, Mohamed Rabah, Polyte, Jacqueline, Gaudin, Aurore, Mercey, Marion, Donati, Flora, Baudesson, Camille, Higgs, Martin R., Picard, Alexandre, Magnan, Christophe, Foufelle, Fabienne, Pawlotsky, Jean-Michel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546027/
https://ncbi.nlm.nih.gov/pubmed/28559285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785030
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