Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity

Autoimmunity is largely prevented by medullary thymic epithelial cells (TECs) through their expression and presentation of tissue-specific Ags to developing thymocytes, resulting in deletion of self-reactive T cells and supporting regulatory T cell development. The transcription factor Prdm1 has bee...

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Pubblicato in:J Immunol
Autori principali: Roberts, Natalie A., Adams, Brian D., McCarthy, Nicholas I., Tooze, Reuben M., Parnell, Sonia M., Anderson, Graham, Kaech, Susan M., Horsley, Valerie
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2017
Soggetti:
Autoimmunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544928/
https://ncbi.nlm.nih.gov/pubmed/28701508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600941
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