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Probing the effects of gating on the ion occupancy of the K(+) channel selectivity filter using 2D IR spectroscopy
The interplay between the intracellular gate and the selectivity filter underlies the structural basis for gating in potassium ion channels. Using a combination of protein semisynthesis, two-dimensional infrared (2D IR) spectroscopy, and molecular dynamics (MD) simulations, we probe the ion occupanc...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5544906/ https://ncbi.nlm.nih.gov/pubmed/28472884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01594 |
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