Instantaneous ion configurations in the K(+) ion channel selectivity filter revealed by 2D IR spectroscopy

Potassium channels are responsible for the selective permeation of K(+) ions across cell membranes. K(+) ions permeate in single file through the selectivity filter, a narrow pore lined by backbone carbonyls that compose 4 K(+) binding sites. Here, we report 2D IR spectra of a semisynthetic KcsA cha...

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Foilsithe in:Science
Main Authors: Kratochvil, Huong T., Carr, Joshua K., Matulef, Kimberly, Annen, Alvin W., Li, Hui, Maj, Michał, Ostmeyer, Jared, Serrano, Arnaldo L., Raghuraman, H., Moran, Sean D., Skinner, J. L., Perozo, Eduardo, Roux, Benoît, Valiyaveetil, Francis I., Zanni, Martin T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544905/
https://ncbi.nlm.nih.gov/pubmed/27701114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag1447
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