Instantaneous ion configurations in the K(+) ion channel selectivity filter revealed by 2D IR spectroscopy

Potassium channels are responsible for the selective permeation of K(+) ions across cell membranes. K(+) ions permeate in single file through the selectivity filter, a narrow pore lined by backbone carbonyls that compose 4 K(+) binding sites. Here, we report 2D IR spectra of a semisynthetic KcsA cha...

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Bibliographic Details
Published in:Science
Main Authors: Kratochvil, Huong T., Carr, Joshua K., Matulef, Kimberly, Annen, Alvin W., Li, Hui, Maj, Michał, Ostmeyer, Jared, Serrano, Arnaldo L., Raghuraman, H., Moran, Sean D., Skinner, J. L., Perozo, Eduardo, Roux, Benoît, Valiyaveetil, Francis I., Zanni, Martin T.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544905/
https://ncbi.nlm.nih.gov/pubmed/27701114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag1447
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