Probing the effects of gating on the ion occupancy of the K(+) channel selectivity filter using 2D IR spectroscopy

The interplay between the intracellular gate and the selectivity filter underlies the structural basis for gating in potassium ion channels. Using a combination of protein semisynthesis, two-dimensional infrared (2D IR) spectroscopy, and molecular dynamics (MD) simulations, we probe the ion occupanc...

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Udgivet i:J Am Chem Soc
Main Authors: Kratochvil, Huong T., Maj, Michał, Matulef, Kimberly, Annen, Alvin W., Ostmeyer, Jared, Perozo, Eduardo, Roux, Benoît, Valiyaveetil, Francis I., Zanni, Martin T.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544906/
https://ncbi.nlm.nih.gov/pubmed/28472884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01594
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