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Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-Type Inactivation and in Recovery from Inactivation
The selectivity filter of K(+) channels contains four ion binding sites (S1–S4) and serves dual functions of discriminating K(+) from Na(+) and of acting as a gate during C-type inactivation. C-type inactivation is modulated by ion binding to the selectivity filter sites but the underlying mechanism...
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| Publicado no: | Structure |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4876015/ https://ncbi.nlm.nih.gov/pubmed/27150040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.02.021 |
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