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Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K(+) channels
K(+) channels distinguish K(+) from Na(+) in the selectivity filter, which consists of four ion-binding sites (S1–S4, extracellular to intracellular) that are built mainly using the carbonyl oxygens from the protein backbone. In addition to ionic discrimination, the selectivity filter regulates the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816462/ https://ncbi.nlm.nih.gov/pubmed/24128761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314356110 |
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