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Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K(+) channels

K(+) channels distinguish K(+) from Na(+) in the selectivity filter, which consists of four ion-binding sites (S1–S4, extracellular to intracellular) that are built mainly using the carbonyl oxygens from the protein backbone. In addition to ionic discrimination, the selectivity filter regulates the...

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Bibliografske podrobnosti
Main Authors: Matulef, Kimberly, Komarov, Alexander G., Costantino, Corey A., Valiyaveetil, Francis I.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816462/
https://ncbi.nlm.nih.gov/pubmed/24128761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314356110
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