Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis

Rhomboids are intramembrane serine proteases conserved in all kingdoms of life. They regulate epidermal growth factor receptor signalling in Drosophila by releasing signalling ligands from their transmembrane tethers. Their functions in mammals are poorly understood, in part because of the lack of e...

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Published in:Sci Rep
Main Authors: Johnson, Nicholas, Březinová, Jana, Stephens, Elaine, Burbridge, Emma, Freeman, Matthew, Adrain, Colin, Strisovsky, Kvido
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544772/
https://ncbi.nlm.nih.gov/pubmed/28779096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07556-3
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