Mammalian EGF receptor activation by the rhomboid protease RHBDL2

The epidermal growth factor receptor (EGFR) has several functions in mammalian development and disease, particularly cancer. Most EGF ligands are synthesized as membrane-tethered precursors, and their proteolytic release activates signalling. In Drosophila, rhomboid intramembrane proteases catalyse...

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Bibliographische Detailangaben
Hauptverfasser: Adrain, Colin, Strisovsky, Kvido, Zettl, Markus, Hu, Landian, Lemberg, Marius K, Freeman, Matthew
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
Schlagworte:
Scientific Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090019/
https://ncbi.nlm.nih.gov/pubmed/21494248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.50
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