Mammalian EGF receptor activation by the rhomboid protease RHBDL2

The epidermal growth factor receptor (EGFR) has several functions in mammalian development and disease, particularly cancer. Most EGF ligands are synthesized as membrane-tethered precursors, and their proteolytic release activates signalling. In Drosophila, rhomboid intramembrane proteases catalyse...

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Main Authors: Adrain, Colin, Strisovsky, Kvido, Zettl, Markus, Hu, Landian, Lemberg, Marius K, Freeman, Matthew
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090019/
https://ncbi.nlm.nih.gov/pubmed/21494248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.50
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