Laddar...
mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells
mTORC1 is known to activate sterol regulatory element-binding proteins (SREBPs) including SREBP-2, a master regulator of cholesterol synthesis. Through incompletely understood mechanisms, activated mTORC1 triggers translocation of SREBP-2, an endoplasmic reticulum (ER) resident protein, to the Golgi...
Sparad:
| I publikationen: | Proc Natl Acad Sci U S A |
|---|---|
| Huvudupphovsmän: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2017
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5544314/ https://ncbi.nlm.nih.gov/pubmed/28696297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705304114 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|