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mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells
mTORC1 is known to activate sterol regulatory element-binding proteins (SREBPs) including SREBP-2, a master regulator of cholesterol synthesis. Through incompletely understood mechanisms, activated mTORC1 triggers translocation of SREBP-2, an endoplasmic reticulum (ER) resident protein, to the Golgi...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5544314/ https://ncbi.nlm.nih.gov/pubmed/28696297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705304114 |
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