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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
Nutrient sensing by the mTOR complex 1 (mTORC1) requires its translocation to the lysosomal membrane. Upon amino acids removal, mTORC1 becomes cytosolic and inactive, yet its precise subcellular localization and the mechanism of inhibition remain elusive. Here, we identified Aster‐C as a negative re...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7507422/ https://ncbi.nlm.nih.gov/pubmed/32648345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949898 |
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