Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy

Continuous contraction–relaxation cycles of the heart require strong and stable connections of cardiac myocytes (CMs) with the extracellular matrix (ECM) to preserve sarcolemmal integrity. CM attachment to the ECM is mediated by integrin complexes localized at the muscle adhesion sites termed costam...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Manso, Ana Maria, Okada, Hideshi, Sakamoto, Francesca M., Moreno, Emily, Monkley, Susan J., Li, Ruixia, Critchley, David R., Ross, Robert S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544289/
https://ncbi.nlm.nih.gov/pubmed/28698364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701416114
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