Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy

Continuous contraction–relaxation cycles of the heart require strong and stable connections of cardiac myocytes (CMs) with the extracellular matrix (ECM) to preserve sarcolemmal integrity. CM attachment to the ECM is mediated by integrin complexes localized at the muscle adhesion sites termed costam...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Manso, Ana Maria, Okada, Hideshi, Sakamoto, Francesca M., Moreno, Emily, Monkley, Susan J., Li, Ruixia, Critchley, David R., Ross, Robert S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544289/
https://ncbi.nlm.nih.gov/pubmed/28698364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701416114
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