Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy

Continuous contraction–relaxation cycles of the heart require strong and stable connections of cardiac myocytes (CMs) with the extracellular matrix (ECM) to preserve sarcolemmal integrity. CM attachment to the ECM is mediated by integrin complexes localized at the muscle adhesion sites termed costam...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Manso, Ana Maria, Okada, Hideshi, Sakamoto, Francesca M., Moreno, Emily, Monkley, Susan J., Li, Ruixia, Critchley, David R., Ross, Robert S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544289/
https://ncbi.nlm.nih.gov/pubmed/28698364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701416114
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