Plasminogen promotes cholesterol efflux by the ABCA1 pathway

Using genetic and biochemical approaches, we investigated proteins that regulate macrophage cholesterol efflux capacity (CEC) and ABCA1-specific CEC (ABCA1 CEC), 2 functional assays that predict cardiovascular disease (CVD). Macrophage CEC and the concentration of HDL particles were markedly reduced...

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Vydáno v:JCI Insight
Hlavní autoři: Pamir, Nathalie, Hutchins, Patrick M., Ronsein, Graziella E., Wei, Hao, Tang, Chongren, Das, Riku, Vaisar, Tomas, Plow, Edward, Schuster, Volker, Reardon, Catherine A., Weinberg, Richard, Dichek, David A., Marcovina, Santica, Getz, Godfrey S., Heinecke, Jay W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543924/
https://ncbi.nlm.nih.gov/pubmed/28768900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92176
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