Plasminogen promotes cholesterol efflux by the ABCA1 pathway

Using genetic and biochemical approaches, we investigated proteins that regulate macrophage cholesterol efflux capacity (CEC) and ABCA1-specific CEC (ABCA1 CEC), 2 functional assays that predict cardiovascular disease (CVD). Macrophage CEC and the concentration of HDL particles were markedly reduced...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Pamir, Nathalie, Hutchins, Patrick M., Ronsein, Graziella E., Wei, Hao, Tang, Chongren, Das, Riku, Vaisar, Tomas, Plow, Edward, Schuster, Volker, Reardon, Catherine A., Weinberg, Richard, Dichek, David A., Marcovina, Santica, Getz, Godfrey S., Heinecke, Jay W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543924/
https://ncbi.nlm.nih.gov/pubmed/28768900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92176
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