Plasminogen promotes cholesterol efflux by the ABCA1 pathway

Using genetic and biochemical approaches, we investigated proteins that regulate macrophage cholesterol efflux capacity (CEC) and ABCA1-specific CEC (ABCA1 CEC), 2 functional assays that predict cardiovascular disease (CVD). Macrophage CEC and the concentration of HDL particles were markedly reduced...

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Pubblicato in:JCI Insight
Autori principali: Pamir, Nathalie, Hutchins, Patrick M., Ronsein, Graziella E., Wei, Hao, Tang, Chongren, Das, Riku, Vaisar, Tomas, Plow, Edward, Schuster, Volker, Reardon, Catherine A., Weinberg, Richard, Dichek, David A., Marcovina, Santica, Getz, Godfrey S., Heinecke, Jay W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543924/
https://ncbi.nlm.nih.gov/pubmed/28768900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92176
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