Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure

Widespread changes in cardiac gene expression occur during heart failure, yet the mechanisms responsible for coordinating these changes remain poorly understood. The Mediator complex represents a nodal point for modulating transcription by bridging chromatin-bound transcription factors with RNA poly...

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Pubblicato in:JCI Insight
Autori principali: Hall, Duane D., Ponce, Jessica M., Chen, Biyi, Spitler, Kathryn M., Alexia, Adrianne, Oudit, Gavin Y., Song, Long-Sheng, Grueter, Chad E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543923/
https://ncbi.nlm.nih.gov/pubmed/28768905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92476
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